Magic™ Rabbit Anti-Human DUSP6 Monoclonal antibody, clone 351414B8

Antibody Isotype

IgG

Clone

351414B8

Species Reactivity

Human

Immunogen

DUSP6 fusion protein

Conjugate

Application Notes

We recommend the following antibodies for sandwich immunoassay (Capture - Detection):
DMAB-CPT1015 - DMAB-CPT1016
Cytometric Bead Array: 2.5-80ng/mL

General Notes

This product (Catalog No. DMAB-CPT1015) is a rabbit-derived monoclonal antibody raised against human DUSP6. It has been affinity purified by Protein A. Dual specificity phosphatase 6 (DUSP6) is a member of the family of mitogen-activated protein kinase (MAPK) phosphatases, which dephosphorylate and inactivate MAPK (PMID: 9858808). The MAPK pathway is an important signal transduction system that serves cellular processes, such as proliferation, differentiation, migration, and apoptosis. DUSP6 resides at chromosome location 12q22-23, which is one of the candidate loci for susceptibility to bipolar disorder and which encodes a phosphatase selective for extracellular signal-regulated kinase (ERK) (PMID: 9205128). DUSP6 inactivates extracellular signal-regulated kinase (ERK), and can act in tumor suppressive pathways, whose expression is reduced in several different types of cancer.
DMAB-CPT1015 is suitable for use in Cytometric Bead Array (2.5-80ng/mL) application.
DMAB-CPT1015 is supplied as a liquid formulation in PBS only. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

dual specificity phosphatase 6; DUSP6; MAP kinase phosphatase 3; MKP 3; MKP3; PYST1

Entrez Gene ID

UniProt ID