Product Overview
Human CD19 (20-291) Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Pro 20 - Lys 291 (Accession # P15391-1).
Predicted N terminal
Pro 20
Molecular Weight
The protein has a calculated MW of 32.0 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin
< 1.0 EU per ug by the LAL method.
Alternative Names
CD19; B4; CVID3; MGC12802
Purity
> 90 % as determined by SDS-PAGE.
Buffer
Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Storage
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Introduction
B-lymphocyte antigen CD19 is also known as CD19 (Cluster of Differentiation 19), is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. It primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. As on T cells, several surface molecules form the antigen receptor and form a complex on B lymphocytes. The (almost) B cell-specific CD19 phosphoglycoprotein is one of these molecules.
Keywords
CD19; B4; CVID3; MGC12802
Citations
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Singh, H; Moyes, JSE; et al. Manufacture of T cells using the Sleeping Beauty system to enforce expression of a CD19-specific chimeric antigen receptor. CANCER GENE THERAPY 22:95-100(2015).
Kozela, E; Juknat, A; et al. Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells. JOURNAL OF NEUROINFLAMMATION 12:-(2015).
COA
Certificate of Analysis
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