The Fowl Adenovirus serotype 4 (FAdV-4) Fiber2 protein is a structural component of the viral capsid that plays a critical role in mediating host cell attachment and determining tissue tropism. Unlike Fiber1, Fiber2 has been strongly associated with the virulence of FAdV-4, particularly in causing hydropericardium-hepatitis syndrome (HHS) in chickens. Fiber2 interacts with host cell receptors to facilitate viral entry and is highly immunogenic, making it a key target for vaccine development and serological detection. Its role in pathogenicity and immunity makes Fiber2 a major focus in FAdV-4 research.
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