The Fowl Adenovirus serotype 4 (FAdV-4) Fiber1 protein is one of the key structural proteins located on the viral capsid, functioning primarily in host cell attachment and virus entry. It binds to specific cellular receptors, initiating the infection process. Fiber1, along with Fiber2, contributes to the tissue tropism and pathogenicity of the virus, particularly in cases of hydropericardium-hepatitis syndrome (HHS) in poultry. Due to its surface exposure and immunogenicity, Fiber1 is commonly studied for its potential in vaccine development and as a target for diagnostic assays.
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