Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea and a well-studied polyphenolic antioxidant. It modulates multiple biological pathways including antioxidant defense, signal transduction, and enzyme activity, and has been investigated for potential benefits in cardiovascular health, cancer prevention, and neuroprotection. EGCG's bioactivity arises from its polyhydroxylated structure, which enables free radical scavenging and interactions with proteins and membranes; however, its bioavailability is limited by rapid metabolism and poor stability. Formulation strategies and delivery systems are active areas of research to enhance EGCG's therapeutic potential.
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