This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009]
Function
GDP binding; GTP binding; NOT S-methyl-5-thioribose-1-phosphate isomerase activity; enzyme regulator activity; contributes_to guanyl-nucleotide exchange factor activity; protein binding; contributes_to translation initiation factor activity;
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