Target
Dihydrostreptomycin
Molecular Weight
730.71 g/mol
Alternative Names
dihydrostreptomycin; DHMS; Vibriomycin
Application Notes
Standards in ELISA
Introduction
Dihydrostreptomycin is a derivative of streptomycin, aminoglycoside antibiotic, with bactericidal property. Dihydrostreptomycin depends on active transport across the bacterial cell membrane before irreversibly binding S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the initiation complex between messenger RNA and the bacterial ribosome thereby causing the misreading of the genetic code resulting in the production of non-functional proteins, consequently leading to bacterial cell death.
Keywords
Dihydrostreptomycin; Streptomycin; Aminoglycoside antibiotic
Citations
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Loomans, EEMG; Van Wiltenburg, J; et al. Neamin as an immunogen for the development of a generic ELISA detecting gentamicin, kanamycin, and neomycin in milk. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 51:587-593(2003).
Baxter, GA; Ferguson, JP; et al. Detection of streptomycin residues in whole milk using an optical immunobiosensor. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 49:3204-3207(2001).