Suitable for use to measure free Denosumab in patient samples.
Recommended antibody pair for pharmacokinetic (PK) bridging assay to measure free drug: CABT-ZB196 - CABT-ZB197
Recommended Working Concentration: 0.001-0.05 μg/ml
Summary
Specifications
Antibody Isotype
IgG1, κ
Clone
0B21
Immunogen
Denosumab
Conjugate
Unconjugated
Applications
Application Notes
Suitable for use in PK bridging ELISA. We recommend the following for sandwich ELISA (Capture - Detection): CABT-ZB196 - CABT-ZB197 Recommended Working Concentration: 0.001-0.05 μg/ml
General Notes
We recommend the following antibody pair to develop a pharmacokinetic (PK) bridging assay to measure free drug: CABT-ZB196 - CABT-ZB197 CABT-ZB197 is recommended for use as a detection antibody when paired with CABT-ZB196 as a capture antibody. Denosumab with trade name Prolia, is an FDA-approved drug for the treatment of patients with osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone. Denosumab is a fully human monoclonal antibody that works as a RANK ligand (RANKL) inhibitor. Denosumab can bind RANKL, preventing RANKL from activating RANK, its receptor on the osteoclast surface.
Target
Alternative Names
Mouse monoclonal antibody to Denosumab/Prolia; AMG 162; Denosumab
Citations
Publication ()
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