Specifications
Images
Density of the zolbetuximab epitope (zolbetuximab molecules bound per cell) on human PC cells. Data are depicted as zolbetuximab molecules bound per cell.
Induced CDC
Specific lysis of CLDN18.2-expressing cells (left panel, endogenous; right panel, transduced) by zolbetuximabinduced CDC.
Target
Alternative Names
huCLDN18.2; CLDN18.2; CLDN; Claudin 18.2; Zolbetuximab
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.
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Citations
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Sahin, U; Koslowski, M; et al. Claudin-18 Splice Variant 2 Is a Pan-Cancer Target Suitable for Therapeutic Antibody Development. CLINICAL CANCER RESEARCH 14:7624-7634(2008).
Arabzadeh, A; Troy, TC; et al. Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis. BMC CANCER 7:-(2007).
COA
Certificate of Analysis
