This paratope-specific antibody binds specifically to the free humanized Fab fragment of certolizumab pegol.
No reaction with human TNFα or certolizumab pegol in complex with TNFα.
Suitable for anti-drug antibody (ADA) assay as a surrogate positive control or reference standard.
Summary
Specifications
Antibody Isotype
IgG1, κ
Clone
AbD34201ia
Immunogen
Certolizumab pegol
Conjugate
Unconjugated
Applications
Application Notes
Suitable for use in ADA bridging ELISA. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
General Notes
This antibody binds specifically to free humanized Fab fragment of certolizumab pegol.It can be used as a calibrator in ADA assay. Certolizumab pegol (Cimzia) is a PEGylated, humanized Fab' fragment of a monoclonal antibody derived using recombinant DNA technology. It is approved for the treatment of various autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and psoriatic arthritis. The drug functions by specifically binding to tumor necrosis factor-alpha (TNF-α), blocking its interaction with receptors and reducing inflammation.
Target
Alternative Names
Certolizumab pegol, Cimzia
Citations
Publication ()
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