Anti-Smad3 Polyclonal Antibody (CABT-L2190) Knockout Validated

Rabbit Anti-Human Smad3 (Phe231~Ser425) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Rat
Immunogen
Recombinant fragment corresponding to human SMAD3 (Phe231~Ser425)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.5-2 ug/ml; 1:480-1900
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Knockout Varification: Lane 1: Wild-type PC3 cell lysate. Lane 2: Smad3 knockout PC3 cell lysate. Predicted MW: 26, 36, 43, 48kd, Observed MW: 43kd
Western Blot. Sample. Human 293T cell lysate.
Western Blot. Sample. Human Jurkat cell lysate.
Western Blot. Sample. Human PC3 cell lysate.
Western Blot. Sample. Rat Pancreas lysate.

Target


Alternative Names
JV15-2; MADH3
Entrez Gene ID
UniProt ID

Product Background


Pathway
AGE/RAGE pathway; Activin signaling; Adherens junction; Adipogenesis; Alpha6-Beta4 Integrin Signaling Pathway; Androgen receptor signaling pathway; Cell cycle; Chagas disease (American trypanosomiasis);

Citations


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References


Garcia-Bermudez, M; Lopez-Mejias, R; et al. SMAD3 rs17228212 Gene Polymorphism Is Associated with Reduced Risk to Cerebrovascular Accidents and Subclinical Atherosclerosis in Anti-CCP Negative Spanish Rheumatoid Arthritis Patients. PLOS ONE 8:-(2013).
Ryu, JK; Kim, WJ; et al. Inhibition of histone deacetylase 2 mitigates profibrotic TGF-beta 1 responses in fibroblasts derived from Peyronie's plaque. ASIAN JOURNAL OF ANDROLOGY 15:640-645(2013).

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