Anti-PSMC1 Polyclonal Antibody (CABT-L2268) Knockout Validated

Rabbit Anti-Human PSMC1 (Met1~Leu440) Polyclonal Antibody for WB

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human, Mouse
Immunogen
Recombinant fragment corresponding to human PSMC1 (Met1~Leu440)
Conjugate
Unconjugated

Applications


Application Notes
Recommended dilution: WB: 0.5-2 ug/ml
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Data Examples


Knockout Varification: Lane 1: Wild-type Jurkat cell lysate. Lane 2: PSMC1 knockout Jurkat cell lysate. Predicted MW: 41, 49kd, Observed MW: 55kd
Figure. Western Blot. Sample. Lane1: Human Lung Tissue; Lane2: Mouse Brain Tissue; Lane3: Human A549 Cells; Lane4: Human Hela Cells; Lane5: Human Jurkat Cells.

Target


Alternative Names
P26S4; S4; p56; 26S proteasome AAA-ATPase subunit RPT2; 26S protease regulatory subunit 4
Entrez Gene ID
UniProt ID

Product Background


Pathway
AMER1 mutants destabilize the destruction complex; APC truncation mutants are not K63 polyubiquitinated; APC truncation mutants have impaired AXIN binding; APC/C-mediated degradation of cell cycle proteins; APC/C:Cdc20 mediated degradation of Securin; APC/C:Cdc20 mediated degradation of mitotic proteins; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell c

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Nahas, SA; Butch, AW; et al. Rapid Flow Cytometry-Based Structural Maintenance of Chromosomes 1 (SMC1) Phosphorylation Assay for Identification of Ataxia-Telangiectasia Homozygotes and Heterozygotes. CLINICAL CHEMISTRY 55:463-472(2009).
Blotta, S; Tassone, P; et al. Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance. BLOOD 114:3276-3284(2009).

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