Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]
Function
nucleotide binding; poly(A) RNA binding; zinc ion binding
Synonyms
ZCRB1; zinc finger CCHC-type and RNA binding motif 1; MADP1; RBM36; MADP-1; SNRNP31; ZCCHC19; zinc finger CCHC-type and RNA-binding motif-containing protein 1; U11/U12-31K; U11/U12 snRNP 31K; U11/U12 snRNP 31 kDa protein; U11/U12 small nuclear ribonucleoprotein 31 kDa protein
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