Product Overview
Blocking/Immunizing peptide for anti-VPS41 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known. [provided by RefSeq, Jul 2008]
Function
metal ion binding; microtubule binding; molecular_function; protein binding; zinc ion binding;
Synonyms
VPS41; vacuolar protein sorting 41 homolog (S. cerevisiae); vacuolar protein sorting 41 (yeast homolog) , vacuolar protein sorting 41 (yeast); vacuolar protein sorting-associated protein 41 homolog; HVSP41; S53; vacuolar assembly protein 41; HVPS41; hVps41p;
Citations
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Harrington, AJ; Yacoubian, TA; et al. Functional Analysis of VPS41-Mediated Neuroprotection in Caenorhabditis elegans and Mammalian Models of Parkinson's Disease. JOURNAL OF NEUROSCIENCE 32:2142-2153(2012).
Angers, CG; Merz, AJ; et al. HOPS Interacts with Apl5 at the Vacuole Membrane and Is Required for Consumption of AP-3 Transport Vesicles. MOLECULAR BIOLOGY OF THE CELL 20:4563-4574(2009).