Human TWIST2 peptide

Specificity

In the embryo, highly expressed in chondrogenic cells. In embryonic skin, expressed in the undifferentiated mesenchymal layer beneath the epidermis which later develops into the dermis. Expressed in early myeloid cells but not in lymphoid cells in the liv

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Contains 1 basic helix-loop-helix (bHLH) domain.

Purity

70 - 90% by HPLC.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014]

Function

DNA binding; RNA polymerase II transcription factor binding transcription factor activity; chromatin binding; protein binding; protein dimerization activity; protein domain specific binding; sequence-specific DNA binding transcription factor activity;

Synonyms

TWIST2; twist family bHLH transcription factor 2; FFDD3; DERMO1; SETLSS; bHLHa39; twist-related protein 2; twist homolog 2; dermis-expressed protein 1; twist-related bHLH protein Dermo1; class A basic helix-loop-helix protein 39; twist basic helix-loop-helix transcription factor 2;