Trans-4-Hydroxyproline [BSA]

Product Overview

Trans-4-Hydroxyproline, BSA-conjugated

Target

Trans-4-Hydroxyproline

Specificity

Trans-4-Hydroxyproline conjugated with bovine serum albumin (BSA).

Nature

Synthetic

Tag/Conjugate

BSA

Purity

Purity is greater than 90.0% as determined by SDS-PAGE.

Format

Lyophilized

Preservative

None

Storage

2-8°C short term, -20°C long term

Reconstitution

Reconstituted in deionized water (250 μg)

Introduction

Hydroxyproline, a non-essential amino acid derived from proline, with no known therapeutic use. Hydroxproline is used as a major component of structural protiens such as collagen, connective tissues, plant cell walls, tendons and ligaments and provides skin elasticity. Vitiman C is required for the conversion process from proline to hydroxyproline, a deficincy in vitiman C can lead to defects in collagen synthesis, thus, resulting in easy bruising, internal bleeding, breakdown of connective tissue of the ligaments and tendons, and increased risk to blood vessel damage. An unusual feature of this amino acid is that, it is not incorporated into collagen during biosynthesis at the ribosomal level, but is formed from proline by a posttranslational modification by an enzymatic hydroxylation reaction.

Keywords

Trans-4-Hydroxyproline; (2S,4R)-4-Hydroxyproline; L-hydroxyproline; HYP; Hydroxyproline; Hypro; H-HYP-OH