Human TINF2 peptide

Specificity

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Nature

Synthetic

Tag/Conjugate

Unconjugated

Alternative Names

The TBM domain mediates interaction with TERF1.

Purity

70 - 90% by HPLC.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010]

Function

NOT DNA binding; protein binding; telomeric DNA binding;

Synonyms

TINF2; TERF1 (TRF1)-interacting nuclear factor 2; TIN2; DKCA3; TERF1-interacting nuclear factor 2; TRF1-interacting nuclear protein 2;