Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW3 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]
Function
methyltransferase activity
Synonyms
TYW3; tRNA-yW synthesizing protein 3 homolog (S. cerevisiae); C1orf171; tRNA wybutosine-synthesizing protein 3 homolog; tRNA-yW-synthesizing protein 3; tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase
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