Specificity
Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in locall
Tag/Conjugate
Unconjugated
SequenceSimilarities
Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily.Contains 5 ANK repeats.
Storage
Shipped at 4°C. After reconstitution store at -20℃. Avoid freeze / thaw cycles.
Antigen Description
This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. [provided by RefSeq, Jul 2013]
Function
calcium channel activity; calmodulin binding; protein binding;
Synonyms
TRPV6; transient receptor potential cation channel, subfamily V, member 6; CAT1; CATL; ZFAB; ECAC2; ABP/ZF; LP6728; HSA277909; transient receptor potential cation channel subfamily V member 6; calcium transport protein 1; epithelial calcium channel 2; calcium transporter-like protein; Alu-binding protein with zinc finger domain; epithelial apical membrane calcium transporter/channel CaT1;
Citations
Publication ()
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