This gene encodes a member of the tumor protein D52 (TPD52) family. The encoded protein contains a coiled-coil domain and may form homo- or hetero-dimer with TPD52 family members. The protein is reported to be involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed, but the full-length nature of some variants has not yet been determined. [provided by RefSeq, Jul 2008]
Function
cysteine-type endopeptidase activator activity involved in apoptotic process; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity;
Synonyms
TPD52L1; tumor protein D52-like 1; tumor protein D53; D53; hD53; MGC8556;
Citations
Publication ()
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