General Notes
This product (Catalog No. CABT-BL3603) is a rabbit-derived polyclonal antibody raised against human TMEM138, targeting the amino acid region 101–162 of the protein. It has been affinity purified by Protein A. TMEM138 is a protein-coding gene located on human chromosome 11q12.2 that encodes a multi-pass transmembrane protein of 162 amino acids, featuring three transmembrane domains and an N-terminal signal sequence, which plays a critical role in ciliogenesis—the assembly and maintenance of primary cilia essential for cellular signaling and sensory functions. The protein product of TMEM138 localizes to the ciliary axoneme, basal body, and vesicles trafficking toward primary cilia, where it facilitates the transport of proteins like Cep290 and is involved in coordinating vesicular delivery during ciliogenesis. Reduced expression of TMEM138, as observed in mouse fibroblasts and inner medullary collecting duct cells, results in shortened cilia and impaired ciliogenesis, highlighting its necessity for proper ciliary structure and function. Expression of TMEM138 is ubiquitous across human tissues, with increasing levels during embryonic development, and it is tightly co-regulated with the adjacent head-to-tail gene TMEM216 through shared cis-regulatory elements bound by transcription factors like RFX4.
CABT-BL3603 is suitable for use in IF/ICC (1:200–1:800) application.
CABT-BL3603 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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