Human TIRAP blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-TIRAP/Mal (Isoform b) antibody

Target

TIRAP / Mal (Isoform b)

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Function

Toll-like receptor 2 binding; Toll-like receptor 4 binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein binding, bridging; protein heterodimerization activity; protein homodimerization activity; protein kinase C binding;

Synonyms

TIRAP; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Toll interleukin 1 receptor (TIR) domain containing adaptor protein; toll/interleukin-1 receptor domain-containing adapter protein; Mal; MyD88 adapter like; wyatt; adapter protein wyatt; adaptor protein Wyatt; MyD88 adapter-like protein; Toll-like receptor adaptor protein; BACTS1; FLJ42305;