The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Function
DNA binding; ferrous iron binding; methylcytosine dioxygenase activity; methylcytosine dioxygenase activity; methylcytosine dioxygenase activity; protein binding; zinc ion binding
Synonyms
TET2; tet methylcytosine dioxygenase 2; MDS; KIAA1546; methylcytosine dioxygenase TET2; tet oncogene family member 2; probable methylcytosine dioxygenase TET2
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