Human ANTXR1 blocking peptide

Product Overview

Blocking/Immunizing peptide for anti-TEM8/Anthrax Toxin Receptor 1 antibody

Target

TEM8 / Anthrax Toxin Receptor 1

Nature

Synthetic

Tag/Conjugate

Unconjugated

Application Notes

For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.

Format

Lyophilized powder

Preservative

None

Storage

Shipped at ambient temperature, store at -20°C.

Entrez Gene ID

Antigen Description

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]

Function

actin filament binding; collagen binding; metal ion binding; protein binding; transmembrane signaling receptor activity;

Synonyms

ANTXR1; anthrax toxin receptor 1; ATR; GAPO; TEM8; 2310008J16Rik; 2810405N18Rik; tumor endothelial marker 8;