TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]).[supplied by OMIM, Mar 2008]
Function
Rab GTPase activator activity
Synonyms
TBC1D1; TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; TBC; TBC1; TBC1 domain family member 1
Citations
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