This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Function
N-acetylglucosamine-6-sulfatase activity; N-acetylglucosamine-6-sulfatase activity; arylsulfatase activity; calcium ion binding; catalytic activity; hydrolase activity; metal ion binding; sulfuric ester hydrolase activity;
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