Human SPPL2B peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function

aspartic endopeptidase activity, intramembrane cleaving; NOT aspartic endopeptidase activity, intramembrane cleaving; protein binding; protein homodimerization activity;

Synonyms

SPPL2B; signal peptide peptidase like 2B; IMP4; PSH4; PSL1; IMP-4; signal peptide peptidase-like 2B; SPP-like 2B; intramembrane protease 4; presenilin-like protein 1; presenilin homologous protein 4;