Widely expressed at low level.
Belongs to the SINA (Seven in absentia) family.Contains 1 RING-type zinc finger.Contains 1 SIAH-type zinc finger.
Cytoplasm. Nucleus. Predominantly cytoplasmic (Probable). Partially nuclear.
The RING-type zinc finger domain is essential for ubiquitin ligase activity.The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family.
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This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]
protein binding; transcription corepressor activity; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity; zinc ion binding;
SIAH2; siah E3 ubiquitin protein ligase 2; hSiah2; E3 ubiquitin-protein ligase SIAH2; siah-2; seven in absentia homolog 2;