Human SIAH2 peptide (DAG-P1980)

Specificity
Widely expressed at low level.
Nature
Synthetic
Tag/Conjugate
Unconjugated
Sequence Similarities
Belongs to the SINA (Seven in absentia) family.Contains 1 RING-type zinc finger.Contains 1 SIAH-type zinc finger.
Cellular Localization
Cytoplasm. Nucleus. Predominantly cytoplasmic (Probable). Partially nuclear.
Alternative Names
The RING-type zinc finger domain is essential for ubiquitin ligase activity.The SBD domain (substrate-binding domain) mediates the homodimerization and the interaction with substrate proteins. It is related to the TRAF family.
Procedure
None
Format
Liquid
Preservative
None
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
UniProt ID
Antigen Description
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]
Function
protein binding; transcription corepressor activity; ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity; zinc ion binding;
Synonyms
SIAH2; siah E3 ubiquitin protein ligase 2; hSiah2; E3 ubiquitin-protein ligase SIAH2; siah-2; seven in absentia homolog 2;

Citations


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References


Tan, JTM; Prosser, HCG; et al. High- density lipoproteins augment hypoxia-induced angiogenesis via regulation of post- translational modulation of hypoxia- inducible factor 1 alpha. FASEB JOURNAL 28:206-217(2014).
MacLeod, RJ; Hayes, M; et al. Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 293:G403-G411(2007).

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