Mouse STAT5A blocking peptide

Product Overview

STAT5a ( C - term ) peptide ( mouse )

Target

STAT5a

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Concentration

0.2 mg/ml

Buffer

PBS with 100ug BSA 0.1% sodium azide

Preservative

0.1% Sodium Azide

Storage

Keep as concentrated solution, aliquot and store at 4°C.

Gene ID

20850

Antigen Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Function

DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; calcium ion binding; double-stranded DNA binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; signal transducer ac

Synonyms

STAT5A; signal transducer and activator of transcription 5A; mammary gland factor STAT5A; STAT5; AA959963;