Human STAT2 blocking peptide

Product Overview

STAT2 ( C - term ) peptide ( human )

Target

STAT2

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Concentration

0.2 mg/ml

Buffer

PBS with 100ug BSA 0.1% sodium azide

Preservative

0.1% Sodium Azide

Storage

Keep as concentrated solution, aliquot and store at 4°C.

Entrez Gene ID

Antigen Description

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Function

DNA binding; calcium ion binding; protein binding; sequence-specific DNA binding transcription factor activity; signal transducer activity;

Synonyms

STAT2; signal transducer and activator of transcription 2, 113kDa; signal transducer and activator of transcription 2, 113kD; signal transducer and activator of transcription 2; STAT113; interferon alpha induced transcriptional activator; P113; ISGF-3; MGC59816;