This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
Function
metal ion binding; phosphatidylinositol-3-phosphate binding; protein binding
Synonyms
ZFYVE26; zinc finger, FYVE domain containing 26; SPG15; FYVE-CENT; zinc finger FYVE domain-containing protein 26; spastizin; FYVE domain-containing centrosomal protein
Citations
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