Human BAG4 blocking peptide

Product Overview

SODD ( N - term ) peptide ( human )

Target

SODD

Nature

Synthetic

Tag/Conjugate

Unconjugated

Concentration

0.2 mg/ml

Buffer

PBS with 0.1% BSA 0.02% sodium azide pH7.2

Preservative

0.02% Sodium Azide

Storage

Upon Receipt - Keep as concentrated solution. Aliquot and store at -20℃ or below. Avoid freeze-thaw cycles.

Entrez Gene ID

Antigen Description

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Function

chaperone binding; poly(A) RNA binding; receptor signaling protein activity;

Synonyms

BAG4; BCL2-associated athanogene 4; SODD; BAG-4; BAG family molecular chaperone regulator 4; silencer of death domains; bcl-2-associated athanogene 4; BAG-family molecular chaperone regulator-4;