This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Function
hydrolase activity;
Synonyms
DCLRE1A; DNA cross-link repair 1A; PSO2; SNM1; SNM1A; DNA cross-link repair 1A protein; SNM1 homolog A; DNA-crosslink repair gene SNM1;
Citations
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