SLX4 peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

Belongs to the SLX4 family.Contains 1 BTB (POZ) domain.

Purity

70 - 90% by HPLC.

Format

Liquid

Preservative

None

Storage

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.

Entrez Gene ID

Antigen Description

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011]

Function

contributes_to 3-flap endonuclease activity; contributes_to 5-flap endonuclease activity; contributes_to crossover junction endodeoxyribonuclease activity; enzyme activator activity; protein binding;

Synonyms

SLX4; SLX4 structure-specific endonuclease subunit; FANCP; BTBD12; MUS312; structure-specific endonuclease subunit SLX4; BTB (POZ) domain containing 12; BTB/POZ domain-containing protein 12; SLX4 structure-specific endonuclease subunit homolog;