This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Function
DNA binding; RNA binding; nucleotide binding; protein binding;
Synonyms
PUF60; poly-U binding splicing factor 60KDa; poly(U)-binding-splicing factor PUF60; FBP interacting repressor; FIR; pyrimidine tract binding splicing factor; Ro ribonucleoprotein binding protein 1; RoBPI; siah binding protein 1; SIAHBP1; roBP1; siah-BP1; ro-binding protein 1; siah-binding protein 1; FBP-interacting repressor; poly-U binding splicing factor PUF60; 60 kDa poly(U)-binding-splicing factor; Ro ribonucleoprotein-binding protein 1; fuse-binding protein-interacting repressor; FLJ31379;
Citations
Publication ()
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