Yeast TRX2 (DAG1756)

Yeast TRX2 (aa 1 - 104), recombinant protein from E. coli

Product Overview
Yeast TRX2 (1 a.a. - 104 a.a.) full-length recombinant protein expressed inEscherichia coli .
Nature
Recombinant
Tag/Conjugate
Unconjugated
Procedure
None
Format
Liquid
Buffer
In 20 mM HEPES, pH 7.0 (10% glycerol)
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1. Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
Keywords
Saccharomyces cerevisiae TRX2; S. cerevisiae TRX2

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