Mouse Monocyte Chemotactic Protein 1 (DAG285)

Mouse Monocyte Chemotactic Protein 1, recombinant protein from E. coli Datasheet

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Product Overview
RecombinantMouse Monocyte Chemotactic Protein-1 (MCP-1) (CCL2/JE). Recombinant MouseMCP-1 is a single, non-glycosylated polypeptide chain containing 125 aminoacids and having a molecular weight of 13,803 Da. The sequence of the firstfive N-terminal amino
Nature
Recombinant
Tag/Conjugate
Unconjugated
Format
Purified, Lyophilized. Reconstitute using sterile deionized water to a concentration 100μg/ml. Further dilutions can be made in other aqueou buffers.
Concentration
Lot specific(OD280nm) (prior to lyophilization)
Buffer
Notapplicable.
Preservative
None
Storage
2-8°C short term, -20°C long term
Introduction
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
Antigen Description
Chemokine(C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokinefamily that is also known as monocyte chemotactic protein-1 (MCP-1) and smallinducible cytokine A2. CCL2 recruits monocytes, memory T cells, and dendriticcells to sites of tissue injury, infection, and inflammation.
Keywords
CCL2; chemokine (C-C motif) ligand 2; HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30; C-C motif chemokine 2; small-inducible cytokine A2; monocyte secretory protein JE; monocyte chemotactic protein 1; monocyte chemoattractant protein 1; monocyte

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