Human Heat Shock Protein 8

Nature

Recombinant

Tag/Conjugate

Unconjugated

Format

Purified, Liquid

Concentration

Lotspecific (BCA method)

Buffer

20mMTris/acetate, pH 7.6 containing 10mM NaCl, 0.1mM EDTA, 0.1mM PMSF and 15mMbetamercaptoethanol

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]

Antigen Description

Heatshock proteins (HSP) are a class of functionally related proteins involved inthe folding and unfolding of other proteins. Their expression is increasedwhen cells are exposed to elevated temperatures or other stress. Thisincrease in expression is transcriptionally regulated. The dramaticupregulation of the heat shock proteins is a key part of the heat shockresponse and is induced primarily by heat shock factor (HSF). HSPs are foundin virtually all living organisms, from bacteria to humans.

Keywords

HSPB8; heat shock 22kDa protein 8; H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22; heat shock protein beta-8; protein kinase H11; alpha-crystallin C chain; E2-induced gene 1 protein; heat shock 27kDa protein 8; small stress protein-like protein HSP22;