Product Overview
Recombinant HAV P3C immunodominant region. Contains a GST fusion partner, was expressed in E. coli. Immunoreactive with HAV positive sera.
Purity
> 90% pure (10% PAGE coomassie staining). Inclusion Bodies
Buffer
10mM Carbonate-bicarbonate buffer, pH 9.6, 0.1% SDS containing 50% glycerol
Storage
2-8°C short term, -20°C long term
Introduction
Hepatitis A Virus (HAV) is a 27nm nonenveloped, spherical, positive stranded RNA virus, classified within the genus hepatovirus of the picornavirus family and is among the smallest and structurally simplest of the RNA animal viruses. A single large polyprotein is expressed from a large open reading frame extending through most of the genomic RNA. This polyprotein is subsequently cleaved by a viral protease (3Cpro) to form three (possibly four) capsid proteins and several nonstructural proteins. HAV genomic replication occurs exclusively in the cytoplasm of the infected hepatocyte by a mechanism involving an RNA-dependent RNA polymerase.
Keywords
HAV P3C; HAV; P3C; Hepatitis A Virus P3C; Hepatitis A Virus; Picornaviridae; Hepatovirus
Citations
Publication ()
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