Product Overview
Recombinant Borrelia burgdorferi outer surface protein A (OspA) is produced in E. coli with a 6×His epitope tag. The recombinant protein has an approximate molecular weight of 29 kDa and demonstrates reactivity with human Borrelia burgdorferi-positive serum.
Purity
> 95% pure (SDS-PAGE)
Concentration
1 mg/ml (Bradford method)
Buffer
20mM Tris-HCl, pH 7.5 containing 10mM beta-mercaptoethanol
Storage
2-8°C short term, -20°C long term
Introduction
Borrelia burgdorferi is a spirochete and the cause of Lyme disease, a tick transmitted illness of humans and animals. B. burgdorferi may persist in humans and animals for months or years following initial infection, despite a robust humoral immune response. B. burgdorferi resembles other spirochetes in that it is a highly specialized, motile, two-membrane, spiral shaped bacteria which lives primarily as an extracellular pathogen. B. burgdorferi has an unusual genome compared with other eubacteria which includes a linear chromosome approximately one megabase in size and numerous linear and circular plasmids.
Keywords
B burgdorferi; Lyme disease; Osp-A; Spirochaetaceae; Borrelia
Citations
Publication ()
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