B. burgdorferi OspA [His], recombinant protein from E. coli
Recombinant Borrelia burgdorferi Osp-A,contains multiple copies of the Osp-A sequence, and contains a 6-HIS epitope tag. Total molecular weight is 85 kDa. It was expressed in E.coli. Reacts with human Borrelia burgdorferi positive serum.
> 95% pure (SDS-PAGE)
1 mg/ml (Bradford method)
20mM Tris-HCl, pH 7.5 containing 10mM beta-mercaptoethanol
2-8°C short term, -20°C long term
Borrelia burgdorferi is a spirochete and the cause of Lyme disease, a tick transmitted illness of humans and animals. B. burgdorferi may persist in humans and animals for months or years following initial infection, despite a robust humoral immune response. B. burgdorferi resembles other spirochetes in that it is a highly specialized, motile, two-membrane, spiral shaped bacteria which lives primarily as an extracellular pathogen. B. burgdorferi has an unusual genome compared with other eubacteria which includes a linear chromosome approximately one megabase in size and numerous linear and circular plasmids.
B burgdorferi; Lyme disease; Osp-A; Spirochaetaceae; Borrelia