B. burgdorferi OspA [His]

Product Overview

Recombinant Borrelia burgdorferi Osp-A,contains multiple copies of the Osp-A sequence, and contains a 6-HIS epitope tag. Total molecular weight is 85 kDa. It was expressed in E.coli. Reacts with human Borrelia burgdorferi positive serum.

Nature

Recombinant

Tag/Conjugate

His

Molecular Weight

85kDa

Purity

> 95% pure (SDS-PAGE)

Format

Purified, Liquid

Concentration

1 mg/ml (Bradford method)

Buffer

20mM Tris-HCl, pH 7.5 containing 10mM beta-mercaptoethanol

Preservative

None

Storage

2-8°C short term, -20°C long term

Introduction

Borrelia burgdorferi is a spirochete and the cause of Lyme disease, a tick transmitted illness of humans and animals. B. burgdorferi may persist in humans and animals for months or years following initial infection, despite a robust humoral immune response. B. burgdorferi resembles other spirochetes in that it is a highly specialized, motile, two-membrane, spiral shaped bacteria which lives primarily as an extracellular pathogen. B. burgdorferi has an unusual genome compared with other eubacteria which includes a linear chromosome approximately one megabase in size and numerous linear and circular plasmids.

Keywords

B burgdorferi; Lyme disease; Osp-A; Spirochaetaceae; Borrelia