Anti-RPRD1A monoclonal antibody (DMABT-H12728)

Mouse anti-Human RPRD1A monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2b
Clone
2C9
Species Reactivity
Human, Mouse, Rat
Immunogen
P15RS (NP_060640, 76 a.a. ~280a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
RPRD1A; regulation of nuclear pre-mRNA domain containing 1A; regulation of nuclear pre-mRNA domain-containing protein 1A; cyclin dependent kinase 2B inhibitor related protein; Cyclin dependent kinase inhibitor 2B related protein (p15INK4B related protein)
Entrez Gene ID
UniProt ID

Product Background


Gene summary
RPRD1A (Regulation Of Nuclear Pre-MRNA Domain Containing 1A) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. An important paralog of this gene is RPRD2. This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16.
Antigen Description
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.

Citations


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References


Kadrofske, MM; Openo, KP; et al. The human LGALS3 (galectin-3) gene: Determination of the gene structure and functional characterization of the promoter. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 349:7-20(1998).

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