This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Function
ubiquitin-protein ligase activity; zinc ion binding;
Synonyms
TRIM69; tripartite motif containing 69; Trif; HSD34; RNF36; E3 ubiquitin-protein ligase TRIM69; ring finger protein 36; RFP-like domain-containing protein trimless;
Citations
Publication ()
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