The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]
Function
RNA polymerase II core promoter proximal region sequence-specific DNA binding; zinc ion binding
Synonyms
DPF2; D4, zinc and double PHD fingers family 2; REQ; UBID4; ubi-d4; zinc finger protein ubi-d4; BAF45D; protein requiem; BRG1-associated factor 45D; apoptosis response zinc finger protein; requiem, apoptosis response zinc finger
Citations
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