Tag/Conjugate
Unconjugated
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. Information available upon request.
Antigen Description
The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008]
Function
ATP binding; N-acylglucosamine 2-epimerase activity; endopeptidase inhibitor activity; protein homodimerization activity;
Synonyms
RENBP; renin binding protein; RBP; RNBP; N-acylglucosamine 2-epimerase; AGE; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase;
Citations
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KUHNLE, U; KELLER, U; et al. IMMUNOFLUORESCENCE OF MINERALOCORTICOID RECEPTORS IN PERIPHERAL LYMPHOCYTES - PRESENCE OF RECEPTOR-LIKE ACTIVITY IN PATIENTS WITH THE AUTOSOMAL-DOMINANT FORM OF PSEUDOHYPOALDOSTERONISM, AND ITS ABSENCE IN THE RECESSIVE FORM. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 51:267-273(1994).
Finnskog, D; Ressine, A; et al. Integrated protein microchip assay with dual fluorescent- and MALDI read-out. JOURNAL OF PROTEOME RESEARCH 3:988-994(2004).
COA
Certificate of Analysis
