Anti-RBFOX2 monoclonal antibody (DMABT-H12892)

Mouse anti-Human RBFOX2 monoclonal antibody for WB, IHC, IF, sELISA, ELISA, RNAi Knockdown Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
5H4
Species Reactivity
Human, Mouse
Immunogen
RBM9 (AAH13115,2a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
RBFOX2; RNA binding protein, fox-1 homolog (C. elegans) 2; RBM9, RNA binding motif protein 9; RNA binding protein fox-1 homolog 2; FOX 2; hexaribonucleotide binding protein 2
Entrez Gene ID
UniProt ID

Product Background


Gene summary
RBFOX2 (RNA Binding Protein, Fox-1 Homolog 2) is a Protein Coding gene. Diseases associated with RBFOX2 include kaposi sarcoma and sarcocystosis. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is RBFOX3. This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
RNA-binding protein that regulates alternative splicing events by binding to 5-UGCAUGU-3 elements. Prevents binding of U2AF2 to the 3-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. RNA binding motif protein 9, also known as RBM9 or FOX-2, is a protein which in humans is encoded by the RBM9 gene. RBM9 is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.

Citations


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References


Dredge, BK; Jensen, KB; et al. NeuN/Rbfox3 Nuclear and Cytoplasmic Isoforms Differentially Regulate Alternative Splicing and Nonsense-Mediated Decay of Rbfox2. PLOS ONE 6:-(2011).

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