Mesoporous hollow hydroxyapatite capped with smart polymer for multi-stimuli remotely controlled drug delivery
MICROPOROUS AND MESOPOROUS MATERIALS
Authors: Chen, Ruixia; Shi, Jun; Zhu, Beibei; Zhang, Li; Cao, Shaokui
Abstract
In this paper, a pH-/thermal-/NIR multi-responsive drug delivery platform based on hollow hydroxyapatite (H-HAP), poly(N-isopropylacrylamide- co-acrylic acid) (PNA) and gold nanorods (AuNRs) were prepared via electrostatic self-assembly. Thermal-sensitive PNA and near-infrared (NIR) responsive AuNRs were capped on the surface of mesoporous hollow HAP to obstruct the initial burst release of HAP and endow the vehicles with multi-responsive drug delivery properties. Notable pH-/thermal-/NIR multi-responsive drug release properties were clearly observed for H-HAP/PNA/AuNRs hybrid microcapsules. In addition, relatively high DOX release could be found for H-HAP/PNA/AuNRs hybrid microcapsules at pH 4.5 upon NIR laser irradiation, due to the corrosion of H-HAP in acidic media and the synergistically photothermal effect between AuNRs and PNA. This study provides a feasible method to fabricate intelligently controllable hybrid drug carriers, which shows great potential in controllable drug delivery.
Conjugating pyrene onto PNA-based fluorescent probes for improved detection selectivity toward double-stranded siRNA
ORGANIC & BIOMOLECULAR CHEMISTRY
Authors: Sato, Yusuke; Takahashi, Yuki; Tanabe, Takaaki; Nishizawa, Seiichi
Abstract
We report on the design of new siRNA-binding fluorescent probes with the improved detection selectivity toward intact double-stranded siRNAs over single-stranded forms by the conjugation of pyrene unit into thiazole orange base surrogate-carrying peptide nucleic acid (PNA) that can simultaneously recognize the 3 '-overhang and double-stranded sequences of target siRNAs.
COA
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