PSME2 blocking peptide

Nature

Synthetic

Tag/Conjugate

Unconjugated

SequenceSimilarities

PSME2 peptide corresponds to 14 amino acids of PSME2.

Purity

> 95 % by SDS-PAGE.

Format

Lyophilized

Preservative

None

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Reconstitution

PSME2 peptide is supplied as 1mg of dried peptide. When the peptide is reconstituted in 1 mL strile water, the concentration will be 1 mg/mL.

Introduction

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Synonyms

PSME2; proteasome (prosome, macropain) activator subunit 2 (PA28 beta); PA28B; REGbeta; PA28beta; proteasome activator complex subunit 2; REG-beta; MCP activator, 31-kD subunit; proteasome activator 28-beta; 11S regulator complex beta subunit; 11S regulator complex subunit beta; cell migration-inducing protein 22; proteasome activator 28 subunit beta; proteasome activator hPA28 subunit beta; activator of multicatalytic protease subunit 2;