This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Function
ARF guanyl-nucleotide exchange factor activity; phospholipid binding; protein binding; signal transducer activity;
Synonyms
PSD; pleckstrin and Sec7 domain containing; TYL; EFA6; PSD1; EFA6A; PH and SEC7 domain-containing protein 1; exchange factor for ARF6; pleckstrin-Sec7 domains-containing; pleckstrin homology and SEC7 domain-containing protein 1;
Citations
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