Anti-PNMA1 monoclonal antibody (DMABT-H12886)

Mouse anti-Human PNMA1 monoclonal antibody for WB, IHC, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
5H7
Species Reactivity
Human, Mouse
Immunogen
PNMA1 (NP_006020, 62 a.a. ~ 160 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
PNMA1; paraneoplastic Ma antigen 1; paraneoplastic antigen MA1; paraneoplastic antigen Ma1; MA1; 37 kDa neuronal protein
Entrez Gene ID
UniProt ID

Product Background


Gene summary
PNMA1 (Paraneoplastic Ma Antigen 1) is a Protein Coding gene. Diseases associated with PNMA1 include paraneoplastic syndromes. An important paralog of this gene is ZCCHC12. This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors.
Antigen Description
Protein Symbol:Q8ND90-PNMA1_HUMANRecommended name:Paraneoplastic antigen Ma1Protein Accession:Q8ND90Secondary Accessions:A8K4L5O95144Q8NG07The function about PNMA1 antigen include protein binding.

Citations


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References


Pellkofer, H; Schubart, AS; et al. Modelling paraneoplastic CNS disease: T-cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in the rat. BRAIN 127:1822-1830(2004).
Hoffmann, LA; Jarius, S; et al. Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 79:767-773(2008).

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