Product Overview
Blocking/Immunizing peptide for anti-PMSCL1 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants.
Function
3-5-exoribonuclease activity; AU-rich element binding; RNA binding; NOT exoribonuclease activity;
Synonyms
EXOSC9; exosome component 9; PMSCL1, polymyositis/scleroderma autoantigen 1, 75kDa; exosome complex component RRP45; p5; p6; PM/Scl 75; polymyositis/scleroderma autoantigen 1 (75kD); RRP45; Rrp45p; autoantigen PM/Scl 1; PMSCL autoantigen, 75kD; exosome complex exonuclease RRP45; polymyositis/scleroderma autoantigen 1, 75kDa; P75 polymyositis-scleroderma overlap syndrome associated autoantigen; P75 polymyositis-scleroderma overlap syndrome-associated autoantigen; PMSCL1; PM/Scl-75;
Citations
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Allmang, C; Petfalski, E; et al. The yeast exosome and human PM-Scl are related complexes of 3 '-> 5 ' exonucleases. GENES & DEVELOPMENT 13:2148-2158(1999).
Yang, CC; Wang, YT; et al. Structural and biochemical characterization of CRN-5 and Rrp46: An exosome component participating in apoptotic DNA degradation. RNA-A PUBLICATION OF THE RNA SOCIETY 16:1748-1759(2010).